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Side effects stopped you before - Quit standard doses because of nausea

This demonstrates how the incretin hormones are dependent on their receptor being present on islet beta-cells to mediate their insulinotropic effects

PMID: 41931082, PMCID: PMC13221856, DOI: 10.1016/j.jacadv.2026.102713.Peer-Reviewed Original ResearchAltmetricConceptsObesity medicationsDuke Clinical Research InstituteBody mass indexObesity measuresOM usePlacebo-controlled trialAnti-obesity pharmacotherapyObesity-related complicationsClinical Research InstituteEvidence-basedExpert panelMass indexDysfunctional adiposityObesity researchClinical trial designObesity pharmacotherapyObesityAction itemsOM developmentEthics of placebo-controlled trialsTrial designStreamlining researchPharmacotherapyAnti-obesityCare Naltrexone/bupropion for binge-eating disorder: A human laboratory investigation of mechanisms McKee S, Lydecker J, Pittman B, Jastreboff A , DiLeone R, Lavery M, Grilo C

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Patients with high-sensitivity GLP1R variants sometimes tolerate slower dose escalation better, while those with lower-sensitivity versions may achieve results faster with fewer GI complaints